First Digital Tablet Approved by FDA to Track Medication-Taking Patterns of Patients
등록일 2019년 01월 07일 수요일
수정일 2017년 11월 15일 수요일
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The world's first digital medicinal tablet has been approved by the Food and Drug Administration.Called ABILIFY MYCITE, its generic name is aripiprazole and it contains a tiny sensor that is activated by the stomach juices after ingestion.The said sensor communicates to a patch worn by the patient.The readings received by the patch are transmitted to a smartphone or tablet, notifying the patient's doctor or health care provider every time the tablet is swallowed by the patient.It passes through the gastrointestinal tract and leaves the body at the end of the digestive system.The digital tablet is designed to help track and prevent patients from skipping their medication, in this case, the aripiprazole for people with schizophrenia, bipolar I disorder, and major depressive disorder.

"The approval of ABILIFY MYCITE, the first digital medicine system, means that for the first time in my years of experience as a psychiatrist, there is an innovative way to provide individuals with serious mental illness, and selected members of their families and care teams, with information on objective medication-taking patterns to help inform the patient's illness management and personalized treatment plan.This information allows the opportunity for an open dialogue with the patient," said Dr.John Kane from the Department of Psychiatry at Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.

Indications and Safety for ABILIFY MYCITE

ABILIFY MYCITE is a drug-device combination composed of an ingestible event marker or IEM sensor and an aripiprazole tablet, indicated in adults for the treatment of the following mental conditions:

- Schizophrenia in adults.

- Bipolar I disorder: acute or maintenance treatment of manic and mixed episodes as monotherapy and as an addition to lithium or valproate.

- Adjunctive treatment for major depressive disorder in adults.

The medication is not approved for the treatment of patients with dementia-related psychosis in the elderly.The effectiveness and safety of the medication have also not been established in pediatric patients.

Contraindication and Adverse Effects of ABILIFY MYCITE

People with hypersensitivity or allergic reaction from aripiprazole will experience pruritus, urticarial or anaphylaxis.The medication has been found with contraindication and/or adverse effects of the following:

- In clinical trials of aripiprazole, it was found to cause an increased incidence of cerebrovascular adverse events, such as stroke and transient ischemic attack in elderly patients with dementia-related psychosis.

- ABILIFY MYCITE can contribute to the neuroleptic malignant syndrome, a potentially fatal disorder that causes muscle rigidity, altered mental status, and autonomic instability.

- Similar with other antipsychotic drugs, ABILIFY MYCITE may increase the risk of developing tardive dyskinesia, a side effect from antipsychotic drugs characterized by stiff and jerky movements of your face and body that you cannot control.

Metabolic changes may also occur caused by atypical antipsychotic drugs such as hyperglycemia or rise of the blood sugar, dyslipidemia or abnormal amounts of lipids, and weight gain.

Why People with Mental Conditions Do Not Take Their Medications

People with mental conditions like depression or schizophrenia suffer from mood swings and may not snap out of the feeling very soon.This may lead them to forget to take their medications that will help reduce the symptoms.However, some people have other ideas why they don't want to take their medications.

1.Some people tend to say, "We want to do it on our own," and leaving the authority as to when to take medications on people with mental conditions can be a problem.Make sure to carefully remind them that their medications prevent symptoms from happening so they will be motivated to take them.

2.Some people want to try different lifestyle techniques to help them control their mental condition.This can be a good motivation and, together with their medication, will really help improve their quality of life.Discuss to them that changing lifestyle is a welcome idea provided they still take their medication.

3.Some people are sensitive to what they put into their bodies, particularly inorganic products.Talk to them about making an exception for the medication because of the debilitating effects of anxiety and depression.

4.Some people would want to improve their mood using natural methods.Help them understand that their mental condition can severely impact their lives and if the medications work, nothing should feel unnatural about it.As long as their treatment makes them live normally, there is no reason to return to the state of being unwell.

5.Some people do not to take medication because of their denial of having a mental condition.This can be complicated to deal with as the patient tends to suffer symptoms from not taking the drugs immediately and from dwelling to the reality of suffering from a disorder.Compassion is the key to help them understand that the medication will prevent symptoms from attacking them and that will lead them to live as normal as possible.You may also need to discuss this with a therapist to ensure that you are willing to listen to the patient's complaints.

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